"Innovative methods for measuring brominated flame retardants in complex matrices – polybrominated
diphenyl ether detection in serum and human brain"
The potential dangers of exposure to polybrominated diphenyl ethers (PBDEs) have been highlighted in
emerging work in neurotoxicology. PBDEs are widespread in human population and comparable concentrations have been detected across biologic matrices because of their lipophilic nature, ability to
bioaccumulate and biomagnify. The ubiquitous presence of PBDEs has given rise to varied hypotheses regarding their role in neurologic and neurodevelopmental diseases. We developed and validated a
novel method for the analysis of PBDEs in serum and post-mortem human brain tissue in order to better understand PBDEs’ association with neurodevelopmental and behavioral toxicity and the progression of neurodegenerative disease.
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